A distinctive advantage of human beings over other animals is our capacity for deploying reason to the advantage of ourselves and our communities. For that capacity to work well, two major problems of brain design must be solved. The first problem—the “Articles of Confederation” (or Arrovian) problem—is that absent a dominant axis for defining and evaluating decisions, the brain will suffer from ineffectiveness and capture by an array of special interests. The second—the “tyranny” (or agency costs) problem—is that a dominant executive power in the brain is a potential threat, in that such a power may reduce systemic welfare by pursuing its own interests. A dominant self-other axis is a possible solution for the problem of disarrayed, unmotivated choice, and a competition between calculative utilitarian reason and pattern-oriented deontological reason is a possible solution for the problem of executive power misaligned with systemic welfare.